Drug Farm is a biotech company focusing on developing innovative therapies for metabolic diseases，adopting novel technologies in genetics to accelerate drug discovery. The company is headquartered in Shanghai, China and an IND enabling center in Jiashan, Zhejiang. Drug Farm is co-founded by the team with extraordinary track record and extensive experience in drug development and technology commercialization. The company has 65 employees. The main products Drug Farm is developing are:
1) DF006: an identified novel small molecule agonist DF-006 to a novel kinase in the innate immunity pathway. DF-006 is used to treat Hepatitis B, cancer, and non-alcoholic steatohepatitis (NASH). A novel approach to treat HBV is to activate the immune system to kill the virus. DF-006 as an innate immunity agonist that works locally in the liver to activate immunity. DF-006 is extremely effective in lowering HBsAg, HBeAg, and HBV DNA in the in vivo HBV-AAV mouse model and human primary hepatocytes infected by HBV. DF-006 has a big therapeutic window in preclinical mouse and monkey.
DF-006 showed great anti-tumor effect in multiple syngeneic mouse models including MC38 colon cancer, Hepa1-6 liver cancer, RM1 prostate cancer, B16 melanoma, and E0771 triple negative breast cancer. It showed synergic effect when combining to PD-1 or PD-L1 therapies.
DF-006 also showed great efficacy in multiple non-alcoholic steatohepatitis (NASH) models including signal transducing adapter molecule (STAM) model, HFD+CCL4 model, CCL4 liver fibrosis model, and choline deficient amino-acid-defined (CDAA) diet model with a big therapeutic window.
2) DF003: a novel kinase as an anti-inflammation drug target to treat Inflammatory Bowel Disease (IBD), obesity, gout and diabetic nephropathy.
3) DF001: a novel DF001 kinase involving in gut motility and obesity. Its substrate DF001 molecule can promote gut motility thus causing weight loss in obesity mouse models. Drug Farm is developing both health food and drug of DF001 molecule and its derivatives to treat obesity and constipation.